The latest on the actors behind our favorite Seattle Grace doctors.

Where is the *Grey’s Anatomy *cast now? See the soapy medical drama’s stars over 20 years after the series’ debut

The latest on the actors behind our favorite Seattle Grace doctors.

By Chris Snellgrove

and Kevin Jacobsen

March 27, 2026 8:00 a.m. ET

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Jessica Capshaw as Arizona Robbins, Chandra Wilson as Miranda Bailey, Katherine Heigl as Izzie Stevens, Justin Chambers as Alex Karev, Eric Dane as Mark Sloan, Sandra Oh as Cristina Yang, Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sara Ramírez as Callie Torres, James Pickens Jr. as Richard Webber, Chyler Leigh as Lexie Grey, and Kevin McKidd as Owen Hunt on 'Grey's Anatomy'. Credit:

Bob D'Amico/Disney General Entertainment Content via Getty

*Grey's Anatomy* has become a television staple, hooking audiences with equal parts riveting medical stories and soapy relationship drama. Creator Shonda Rhimes' addictive concoction has kept viewers entertained since the medical series first premiered in March 2005, thanks in no small part to its terrific ensemble cast.

Viewers fell in love with the original cast, including Ellen Pompeo, Patrick Dempsey, Sandra Oh, Katherine Heigl, T.R. Knight, Justin Chambers, James Pickens Jr., and Chandra Wilson — each of whom became stars or increased their stardom through their respective tenures on the show. Many new cast members have come and gone in subsequent seasons, but we'll always remember them for *Grey's*, no matter where their careers take them.

Now, on the 21st anniversary of the show's premiere, we're looking at some of *Grey's Anatomy'*s most notable cast members and tracking where they are now.**

Ellen Pompeo (Dr. Meredith Grey)

Ellen Pompeo as Dr. Meredith Grey on 'Grey's Anatomy'; Ellen Pompeo attends the 75th Primetime Emmy Awards at Peacock Theater on Jan. 15, 2024, in Los Angeles, Calif.

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Ellen Pompeo demonstrated her big-screen chops in the movies *Moonlight Mile* (2002) and *Daredevil *(2003), but the small screen made her a household name. That's all thanks to *Grey's Anatomy*, where she plays the titular character, Dr. Meredith Grey.

"I have the best relationship with pretty much all of the original cast," Pompeo told *InStyle*'s* Ladies First* podcast in 2021. "Not everybody, but I really stay in touch with a lot of them, and we just have the best time. I just love them. There's like a deep affection I have for that original cast because we went through something that only a few people can relate to."

Pompeo has been part of *Grey's Anatomy* since its start in 2005. For a while, it looked like she might never cease her full-time commitment to the show. She began appearing in fewer episodes starting in season 19, though she still regularly provides her signature voiceover narration.

She took on her first live-action role since she began *Grey's Anatomy* with the 2025 Hulu limited series *Good American Family*.* *She continues to serve as an executive producer on *Grey's Anatomy*.

The actor married music producer Chris Ivery in 2007. They have three children together.

Patrick Dempsey (Dr. Derek Shepherd)

Patrick Dempsey as Dr. Derek Shepherd on 'Grey's Anatomy'; Patrick Dempsey arrives for the 'Ferrari' premiere at the Directors Guild of America on Dec. 12, 2023, in Los Angeles, Calif.

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Patrick Dempsey already had a reputation as a dreamboat thanks to films like *Can't Buy Me Love *(1987) and *Sweet Home Alabama* (2002) by the time he joined *Grey's Anatomy *in 2005. Neurosurgeon Derek Shepherd is affectionately dubbed "McDreamy," and that nickname has stuck to the actor well past his official departure from the series in 2015.

Fans will always remember when his character was shockingly killed off in season 11. In a 2015 interview with EW, the actor discussed how he felt about retiring the role that catapulted him to stardom. "I knew it would be heavy like that. I didn't realize until we did our interview that it was really over," he said. "It started to dawn on me that this is coming to an end, which is why I think I was so moved by it. It was the first time I really stepped back and was starting to witness and to reflect on what had happened."

That didn't stop writers from bringing McDreamy back in flashbacks and dream sequences, though, notably appearing in Meredith's visions while on a ventilator in season 17. Dempsey has since starred in movies like *Bridget Jones's Baby* (2016), Eli Roth's *Thanksgiving* (2023), and *Ferrari* (2023). Longtime fans also enjoyed his turn in Disney's *Disenchanted* (2022), reprising his role from *Enchanted* (2007). Dempsey returned to television in 2026 as the lead of Fox’s crime drama, *Memory of a Killer*.

When he's not in front of the camera, Dempsey is quite fond of auto racing and has competed in many series. He's also well-known for his philanthropic work, namely founding the Patrick Dempsey Center at Central Maine Medical Center in 2008 during his now-deceased mother's bouts with cancer.

Dempsey was married to his former manager and acting coach, Rochelle "Rocky" Parker, from 1987 to 1994. He later married Jillian Fink in 1999, with whom he shares three children. The couple nearly divorced in 2015, but they reconciled the following year.**

Sandra Oh (Dr. Cristina Yang)

Sandra Oh as Dr. Cristina Yang on 'Grey's Anatomy; Sandra Oh at the Family Day global premiere of 'The Tiger's Apprentice' held at Paramount Pictures Studio Sherry Lansing Theater on Jan. 27, 2024, in Los Angeles, Calif.

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Sandra Oh soon became one of TV's most familiar faces as Cristina Yang, a surgical intern whose drive and ambition eventually made her a cardiothoracic surgical fellow. Oh played the hard worker and fierce friend of Meredith Grey for 10 seasons.

Even after Oh left *Grey’s Anatomy* in 2014, fans still wondered if she would ever return. "It's so funny. Every year, it's like I hear that I'm coming back to the show," she told EW in 2018. "But what I realize is, in a way that I'm really pleased and grateful for, is that the show is continuing on with its life, and that the show and the people who are still attached to the show are still attached to Cristina. It means a lot to me."

Oh's most prominent project since then is the hit spy series *Killing Eve*, on which she played the titular character and served as an executive producer. The role earned her a second Golden Globe in 2015, having previously won for *Grey's Anatomy* in 2005. She also racked up a whopping 11 Emmy nominations between the two shows. Oh won her first Emmy in 2024 as one of the producers on Best Television Movie winner *Quiz Lady*, in which she also starred.

She's done substantial voice work as well, notably for Pixar's *Turning Red *(2022), Netflix’s *She-Ra and the Princesses of Power*, and the Amazon Prime animated series *Invincible*.

Oh was previously married to her *Sideways* director Alexander Payne from 2003 to 2006.

Katherine Heigl (Dr. Izzie Stevens)

Katherine Heigl as Dr. Izzie Stevens on 'Grey's Anatomy'; Katherine Heigl attends the 75th Primetime Emmy Awards at Peacock Theater on Jan. 15, 2024, in Los Angeles, Calif.

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Katherine Heigl had an eclectic early career before joining the original *Grey's Anatomy *cast in 2005 as Dr. Izzie Stevens. She spliced her tenure on the medical drama with rom-com roles in *Knocked Up *(2007) and *27 Dresses *(2008), but *Grey's *took up most of her time. That hard work paid off, however, when she won an Emmy for Outstanding Supporting Actress in a Drama Series in 2007.

Somewhat notoriously, the actress withdrew her name from awards consideration in 2008, explaining in a statement, per *The Hollywood Reporter*, "I did not feel that I was given the material [in season 4] to warrant an Emmy nomination and in an effort to maintain the integrity of the academy organization." This led to a public perception that Heigl was a diva. She left the series shortly thereafter in season 6 and later expressed regrets about the ordeal.

"I am disappointed in myself for allowing that perception to exist," she told EW in 2010. "There's nothing more gross than [the idea of] somebody in my position being ungrateful...And I hope that in the coming years I can change people's minds about that. The six years [she spent on *Grey's*] were important years, and I don't want them to be demeaned."

After leaving *Grey's Anatomy* behind, Heigl appeared in movies like *One for the Money* (2012) and played Samantha Wheeler in the last two seasons of *Suits*. She also starred on and produced Netflix’s *Firefly Lane*.

Heigl married singer Josh Kelley in 2007, and they share three children. Heigl has received awards for her activism surrounding adoption, animal welfare, and cancer awareness.

Justin Chambers (Dr. Alex Karev)

Justin Chambers as Dr. Alex Karev on 'Grey's Anatomy'; Justin Chambers at the premiere of 'The Offer' held at Paramount Pictures Studio on April 20, 2022, in Los Angeles, Calif.

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A former Calvin Klein and Armani model, Justin Chambers' acting career didn't truly take off until he was cast on *Grey's Anatomy *as Dr. Alex Karev, who starts as a surgical intern before becoming a resident and later a pediatric surgeon.

Chambers played the role for 14 years, which is no small feat. When EW asked why he returned for season 13, the actor put it simply: "[It's] a job. I like having a job. I like the people I work with. My boss is awesome. It's great. Why not? I've got nowhere better to be. This is where I'm supposed to be, and I'm enjoying it."

Eventually, Chambers *did *have somewhere better to be. After leaving *Grey’s Anatomy* in 2020, he portrayed Marlon Brando in the Paramount+ miniseries *The Offer* (2022) and appeared in an episode of the Fox anthology series *Accused* in 2024.

He's been married to former model agency booker Keisha Chambers since 1993. They have five children together.

T. R. Knight (Dr. George O’Malley)

T.R. Knight as Dr. George O'Malley on 'Grey's Anatomy'; T.R. Knight arrives for HBO's 'The Flight Attendant' season 2 premiere at the Pacific Design Center on April 12, 2022, in West Hollywood, Calif.

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T.R. Knight's breakout role was playing Dr. George O'Malley on *Grey's Anatomy*, and he even received an Emmy nomination for his performance in 2007. The actor walked away from the show (and a lucrative contract) after five seasons for a number of reasons. According to him, most issues boiled down to strained communication with showrunner Shonda Rhimes and uncertainty about his character's future, in addition to coming out as gay.

"There just comes a time when it's so clear that moving on is the best decision," Knight told EW in 2009. "There are a lot of people who would like to be in my position. But in the end, I need to be fulfilled in my work."

He’s since played notable public figures such as J. Edgar Hoover on *Genius: Einstein* and Reince Priebus on *The Comey Rule*, in addition to costarring on *The Flight Attendant* alongside Kaley Cuoco. A prolific theater actor, Knight most recently played Henry Creel's father, Victor, in *Stranger Things: The First Shadow* on Broadway.

Knight has been married to dancer Patrick B. Leahy since 2013.

Chandra Wilson (Dr. Miranda Bailey)

Chandra Wilson as Dr. Miranda Bailey on 'Grey's Anatomy'; Chandra Wilson attends the 75th Primetime Emmy Awards at Peacock Theater on Jan. 15, 2024, in Los Angeles, Calif.

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After making an impressive stage debut in the early-'90s, Chandra Wilson landed minor screen parts like her turn in *Philadelphia *(1993). But her breakout role was playing Dr. Miranda Bailey on *Grey's Anatomy*, beginning the show as a general surgery resident who works her way up the hospital ladder. Wilson also climbed high in the acting world, earning four Emmy nominations for Outstanding Supporting Actress in a Drama Series between 2006 and 2009.

Despite these impressive accomplishments, she would still worry about her character getting killed off and how that might impact her career. "It's not even anxiety. It's just the reality of what we do. I never get so comfortable that I ever forget that," Wilson told EW in 2010. "What we do as actors is really about decisions that get made in rooms with desks. And people change their minds all the time about things...So you make the most of it and you learn as much as you can."

Wilson continues to star in *Grey’s Anatomy*; her character also appeared in two episodes of *Private Practice *in 2009 and 24 episodes of *Station 19* from 2018 to 2024.

She has three children with her longtime partner. Wilson became the spokesperson for the Cyclic Vomiting Syndrome Association after her daughter, Sasha, was diagnosed with the disease in 2010, and even directed a *Grey's Anatomy* episode showcasing the condition (season 9’s "Second Opinion"). She is also an advocate for treating substance abuse and mental health disorders.

James Pickens Jr. (Dr. Richard Webber)

James Pickens Jr. as Dr. Richard Webber on 'Grey's Anatomy'; James Pickens Jr. attends the 75th Primetime Emmy Awards at Peacock Theater on Jan. 15, 2024, in Los Angeles, Calif.

Getty; Neilson Barnard/Getty

Before coming to *Grey's Anatomy* in 2005, James Pickens Jr. played Chuck Mitchell on *Roseanne* and Deputy Director Alvin Kersh on *The X-Files*. However, he's still best known for playing Dr. Richard Webber, who begins the show as the chief of surgery at Seattle Grace Mercy West Hospital. The veteran actor has faced many creative challenges over the years, though Dr. Webber's arc in which he grapples with alcoholism hit especially close to home.

"My dad struggled with alcoholism toward the end of his life, so I got to watch him struggle, and he battled it valiantly," Pickens Jr. told EW in 2020. "I think the thing that I was most proud of was the fact that that storyline helped me to understand what that day-to-day struggle was like."

The actor continues to star in *Grey’s Anatomy*, though he found the time to reprise his Chuck Mitchell role for the 2018 *Roseanne* reboot and its spinoff, *The Conners*. In November 2025, his *Grey’s* character was revealed to have cancer. Pickens Jr. used his platform at the time to share his own diagnosis of prostate cancer and speak up about the importance of early cancer screenings.

Pickens Jr. is married to former Musique member Gina Taylor, with whom he shares two children. He was inducted into the National Multicultural Western Heritage Museum in 2019 for his impressive cultural contributions to TV and film.

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Isaiah Washington (Dr. Preston Burke)

Isaiah Washington as Dr. Preston Burke on 'Grey's Anatomy'; Isaiah Washington attends 'Behind the Movement' Los Angeles premiere at Harmony Gold Theatre on Feb. 7, 2018, in Los Angeles, Calif.

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Isaiah Washington played Dr. Preston Burke, a cardiothoracic surgeon who enters a tumultuous relationship with Cristina. His contract was not renewed at the end of season 3 following revelations of him using a homophobic slur to refer to costar T.R. Knight.

Post-*Grey's*, Washington appeared in various films and made a handful of TV appearances before starring as Thelonious Jaha on *The 100* from 2014 to 2018. He went on to recur on shows like *Survivor's Remorse* and *P-Valley*. In 2025, he appeared in the films *James the Second*, *Dashing Through the Snow*, and *Oscar Shaw*.

Washington has been married to his wife, Jenisa Garland, since 1996; they have three children together.

Kate Walsh (Dr. Addison Montgomery)

Kate Walsh as Dr. Addison Montgomery on 'Grey's Anatomy'; Kate Walsh attends the 'Emily in Paris' season 3 world premiere at Theatre Des Champs Elysees on Dec. 6, 2022, in Paris, France.

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Kate Walsh began starring on the medical drama in 2005 as neonatal surgeon Dr. Addison Montgomery. The actress soon got her own spinoff in 2007, with *Private Practice** *following Addison after she leaves Seattle Grace Hospital for a co-op wellness clinic in Los Angeles.

That runaway success might have surprised some actors, but not Walsh. She told PEOPLE in 2021 that she had a premonition that *Grey's Anatomy* was destined for greatness. "Sometimes I do feel like I get a little witchy about things," she said. "I was like, 'This is a great show.' Even before it even had an airtime...And here we are...It definitely changed my life."

In many ways, Addison was a character that Walsh just couldn’t quit. She stopped appearing regularly on *Grey's Anatomy* after season 3, though she still returned for occasional episodes. After *Private Practice* ended in 2013, she was able to focus on other projects like *13 Reasons Why*, *The Umbrella Academy*, and *Emily in Paris*. In 2021, she officially rejoined the *Grey's *cast in a guest-starring capacity.

Walsh was married to Alex Young from 2007 to 2010. She is currently engaged to Andrew Nixon, whom she met on an exciting expedition to Antarctica.

Sara Ramírez (Dr. Callie Torres)

Sara Ramírez as Dr. Callie Torres on 'Grey's Anatomy'; Sara Ramírez at the New York premiere of 'And Just Like That' held at MoMA on Dec. 8, 2021, in New York City.

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Before coming to *Grey’s Anatomy* in 2006, Sara Ramírez was primarily known for their stage work, notably winning a Tony award for *Spamalot*. They followed this success with an 11-season stint as Dr. Callie Torres, an orthopedic resident turned attending surgeon.

Ramírez, who is bisexual and came out as non-binary in 2020, had pitched making Callie bisexual to showrunner Shonda Rhimes. Dr. Torres thus became an early marker of queer representation on primetime television.

"Being part of the Shondaland family was one of the greatest honors of my life, one of the greatest privileges," Ramírez told PEOPLE in 2021. "It taught me so much, portraying a character that a lot of folks had not seen on TV, including myself. I will always have a soft tender place in my heart for that work family and that role. It was the role of a lifetime."

After leaving *Grey’s Anatomy *in 2016, Ramírez played political strategist Kat Sandoval on *Madam Secretary* and Che Díaz on *And Just Like That*. They also lent their voice to Disney’s *Sofia the First* as Queen Miranda from 2012 to 2018 and will reprise their role in the upcoming sequel series, *Sofia the First: Royal Magic*.

Ramírez married Ryan DeBolt in 2012. The couple later separated in 2021 and divorced in 2024.

Eric Dane (Dr. Mark Sloan)

Eric Dane as Dr. Mark Sloan on 'Grey's Anatomy'; Eric Dane attends the Global Down Syndrome Foundation's 2022 Be Beautiful Be Yourself fashion show on Nov. 12, 2022, in Denver, Colo.

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Eric Dane became well-acquainted with audiences as Dr. Mark Sloan, a handsome plastic surgeon and frenemy of McDreamy who is likewise dubbed McSteamy.

Dane left *Grey's Anatomy* in 2012 to focus on other projects, including playing Tom Chandler on TNT’s *The Last Ship*. The actor later made waves as the complicated and sinister Cal Jacobs on HBO's *Euphoria*. On the big screen, he appeared in such films as *X-Men: The Last Stand *(2006), *Burlesque *(2010), and *Bad Boys: Ride or Die* (2024).

Dane died at the age of 53 in February 2026, following complications of ALS. He is survived by his wife, actress Rebecca Gayheart, and their two children.

Chyler Leigh (Dr. Lexie Grey)

Chyler Leigh as Dr. Lexie Grey on 'Grey's Anatomy'; Chyler Leigh attends 'The Way Home' press junket during day two of the 12th SCAD TVfest on Feb. 8, 2024, in Atlanta, Ga.

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Chyler Leigh joined the *Grey's Anatomy* cast in season 3 as Meredith Grey’s half-sister, Lexie, a surgical intern who eventually becomes a surgical resident. She also has a dizzying relationship with Eric Dane's Mark Sloan throughout her tenure.

Leigh stayed on *Grey's Anatomy* until that infamous plane crash episode in season 8, though she briefly reprised her role for one of Meredith's dream sequences while on a ventilator due to COVID-19 in season 17.

"To be part of that was obviously very special," Leigh told PEOPLE in 2021. "And to be able to close the chapter for Lexie, and to appear in a way where she's not eaten by wolves. Kind of bring a little life back to it... It was a special experience to be able to be part of that."

The actor's biggest role post-*Grey's *has been playing Alex Danvers on the CW drama *Supergirl*. As the titular heroine's sister, she also appeared in other Arrowverse shows like *Legends of Tomorrow* and *The Flash*. She currently stars in and produces the Hallmark Channel series *The Way Home*.

Leigh has been married to Nathan West since 2002. They have three children together.

Kevin McKidd (Dr. Owen Hunt)

Kevin McKidd as Dr. Owen Hunt on 'Grey's Anatomy'; Kevin McKidd. at the Walt Disney Company's Emmys party held at Otium on Jan. 15, 2024, in Los Angeles, Calif.

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*Grey's Anatomy* has been Kevin McKidd's biggest project to date. He's played Dr. Owen Hunt, a trauma surgeon who suffers from PTSD after serving in Iraq, since season 5.

"We've worked on making sure this isn't sort of a fluffy representation of somebody who has this problem," he told EW in 2009. "He's a good guy. He's just deeply damaged right now...We didn't know how much we were going to deal with the aftermath of being in the Iraq War situation...But we realized pretty quickly that there was a lot there."

The Scottish actor is scheduled to depart the series at the end of season 22. During his tenure, he has taken on other roles, including playing Poseidon in *Percy Jackson & the Olympians *(2010), voicing characters in *Brave *(2012) and on *Star Wars: Rebels*, and appearing in 2024's *It Ends With Us*.

McKidd has been married twice, first to Jane Parker from 1999 to 2017, and then to Arielle Goldrath from 2018 to 2023. He has two children from each marriage and is currently dating actress Danielle Savre.

Jessica Capshaw (Dr. Arizona Robbins)

Jessica Capshaw as Dr. Arizona Robbins on 'Grey's Anatomy'; Jessica Capshaw attends the 'West Side Story' New York premiere at Rose Theater, Jazz at Lincoln Center on Nov. 29, 2021, in New York City.

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Jessica Capshaw had ample acting experience before *Grey’s Anatomy*, but it was playing Dr. Arizona Robbins (the chief of pediatric surgery) that won her millions of fans. Capshaw initially signed on for three episodes, but she stuck around for the rest of season 5 and was promoted to main cast billing the following year.

Fans were surprised when Capshaw's character lost a leg, as was the actor herself. “It was completely shocking to me,” she told TVLine in September 2012. “And then I had a chance to metabolize the information and think about the possibilities. And then when we got back to work I was really like, ‘This is crazy. This is such an insane responsibility.’ There are so many different levels to it, and there were certainly levels that had not happened or been around for Arizona in this particular story. So it was shocking, but once I kind of leaned into it [I realized it] was rife with possibility. This was like a wallop of a new dimension to play.”

Her character also made an impact on the LGBTQ+ community due to her onscreen relationship with Sara Ramírez’s Callie Torres. Fans were upset when she was written off the show in 2018, but she returned as a guest star for season 20 in 2024.

Capshaw has also appeared in films like *Holidate* (2020) and *Dear Zoe* (2022) as well as the Hulu series *Tell Me Lies* (2022). She now stars on the ABC medical drama *Nashville 9-1-1* as the spouse of the fire department’s captain.

The actress married entrepreneur Christopher Gavigan in 2004. They have four children together. She is the daughter of actress Kate Capshaw and stepdaughter of director Steven Spielberg.

Camilla Luddington (Dr. Josephine “Jo” Wilson)

Camilla Luddington as Dr. Josephine 'Jo' Wilson on 'Grey's Anatomy'; Camilla Luddington attends the Walt Disney Company Emmys party at Otium on Jan. 15, 2024, in Los Angeles, Calif.

Steven Baffo/ABC via Getty; Michael Tullberg/FilmMagic

Camilla Luddington's career took off in 2012. She joined the *Grey’s Anatomy *cast in season 9 as Dr. Josephine "Jo" Wilson, and remains on the show to this day.

“It isn't about keeping it interesting and new, because every single season it's really exciting," Luddington told EW in 2021. "The writers always have storylines that are so surprising and change everything. There's no element of, 'Ugh, how do I keep this interesting for myself?'"

She continued, "Actually, when you sit with a character for this long, things in their life start to parallel with yours. When I started off, I was dating my now husband. Now I'm married and have children and feel more settled in my career, and Jo is excelling in her career and having kids. It's like growing with a buddy. That's the surprising part of the experience, when you sit with somebody for that long. You're so invested."

In 2019, Luddington married Matthew Alan, with whom she is raising two children. When not appearing on *Grey's Anatomy*, Luddington has done voice work as Lara Croft in the *Tomb Raider* video games and even did motion capture for the character.

Caterina Scorsone (Dr. Amelia Shepherd)

Caterina Scorsone as Dr. Amelia Shepherd on 'Grey's Anatomy'; Caterina Scorsone attends the Global Down Syndrome Foundation's 15th annual Be Beautiful Be Yourself fashion show at Sheraton Downtown Denver Hotel on Nov. 18, 2023, in Denver, Colo.

Raymond Liu/ABC via Getty; Tom Cooper/Getty

Most audiences hadn't heard of Caterina Scorsone before *Grey's Anatomy* (unless they happened to watch the Canadian shows *Mr. Dressup or* *Power Play*). She's starred in the medical drama since 2010 as Dr. Amelia Shepherd, who also became a partner at Oceanside Wellness Group on *Private Practice*. What's more, the character appeared in five episodes of *Station 19*.

Scorsone was married to Rob Giles from 2009 to 2020. They have three children together, one of whom has Down syndrome, which inspired the actor to become an advocate.

"One thing that changes when you have kids is that nothing is in your control anymore," she told PEOPLE in 2020. "You have to roll with whatever is happening and there are people that are now in your life very intimately and in your space who have distinctly different personalities from you."

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